The use and development of High Performance Computing in Latin America is steadily growing. The capabilities provided by clusters, grids, and distributed systems promote research and innovation. At the same time, many applications heavily rely on HPC infrastructure. Building on the great success of the previous five editions, this year the LatinAmerica High Performance Computing Conference (CARLA) will be held in Turrialba, CostaRica, from September 25 to 27, 2019. The main goal of CARLA 2019 is to provide a regional forum fostering the growth of the HPC community in Latin America through the exchange and dissemination of new ideas, techniques, and research in HPC and its application areas.