The use and development of High Performance Computing in Latin America is steadily growing. New challenges come from the capabilities provided by clusters, grids, and distributed systems for HPC, promoting research and innovation in this area. Building on the great success of the previous five editions, this year the Latin American High Performance Computing Conference (CARLA) 2019 will be held in Turrialba, Costa Rica, from September 25 to 27. The main goal of CARLA 2019 is to provide a regional forum fostering the growth of the HPC community in Latin America through the exchange and dissemination of new ideas, techniques, and research in HPC. The conference will feature invited talks from academy and industry, short- and full-paper sessions presenting both mature work and new ideas in research and industrial applications.